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These results, together with a former report demonstrating that a little-molecule ACKR3 agonist CCX771 reveals anxiolytic-like conduct in mice,2 assistance the strategy of focusing on ACKR3 as a novel way to modulate the opioid method, which could open up new therapeutic avenues for opioid-linked Issues.Tabernaemontana divaricata Conolidine is an i